GQ-16 lator 1 Smiles: O=C(NC1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1NCC1=CC=NC=C1

Smiles: O=C(NC1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1NCC1=CC=NC=C1

14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h2-12

Chemical Name: methyl N-{1-[2-(5-{4'-[2-(1-{2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl)-1H-imidazol-5-yl]-[1

Molecular Weight: 904

CAS Number: 1197194-41-4

GQ-16 lator 1 Smiles: O=C(NC1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1NCC1=CC=NC=C1GQ 16 is a novel partial agonist of peroxisome proliferator activated receptor (PPAR) involved in promoting insulin sensitization . PPAR is mainly involved in fat cell differentiation and insulin sensitivity. In vitro: GQ 16 was an effective inhibitor of Cdk5 mediated phosphorylation of PPAR, exhibiting a Ki value of 160 nM. GQ 16 was specific for PPAR and possessed no detectable activity when tested for the ability to activate other PPAR subtypes