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Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations
InChi: InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H
8(10):e77934
Smiles: CC(C)OC(=O)[C@H](C)N[P@](=O)(CO[C@H](C)CN1C=NC2=C1N=CN=C2N)OC1C=CC=CC=1
Formestane binds irreversibly to and inhibits the enzyme aromatase
HM Janelia Fluor® 526, SE Size:10mg solid Chemical-induced read through of prematureHM Janelia Fluor 526, SE is a spontaneously blinking green emitting dye and a hydroxymethyl derivative of JF526. It is suitable for super resolution imaging including dSTORM, STED and single molecule localization spectroscopy (SMLSM). The spontaneous blinking properties of HM Janelia Fluor 526, avoids the requirement for strongly reducing dSTORM buffers. It is also suitable for conventional confocal microscopy and live cell imaging. Fluorogenic