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CAS Number: 1316214-52-4
Using normal and tumor human/murine cell lines
PubMed PMID: 25449811
mitochondrial dysfunction and improves ventricular function in post-MI cardiomyopathy rats
Epigenetics
PLX-4720 - CAS# 918505-84-7 60209 CAS Number: 1316214-52-4PLX 4720, CAS No. 918505 84 7, is a 7 azaindole derivative that inhibits B Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX 4720 preferentially inhibits the active B Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. Product information CAS Number: 918505 84 7