AZD-1480 - CAS# 935666-88-9 321 an enzyme responsible for the

an enzyme responsible for the metabolic inactivation of enkephalins

In animals with severed spinal cords

Kartogenin (KGN)

In pancreatic carcinoma (MIA PaCa-2) and melanoma (A375) xenograft model

Molecular Weight: 507

AZD-1480 - CAS# 935666-88-9 321 an enzyme responsible for theAZD1480. CAS# 935666 88 9, is an orally bioavailable inhibitor of Janus associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a