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InChiKey: RTIXKCRFFJGDFG-UHFFFAOYSA-N
TE6 and TE10 xenografts in nude mice
Nesland JM
130663-39-7 (free base)
PubMed PMID: 15999992
PHT-427 Size:2mg solid InChiKey: RTIXKCRFFJGDFG-UHFFFAOYSA-NPHT 427 is an AKT inhibitor that inhibits AKT and PDPK1 at low micromolar concentrations in numerous cancer cell lines and exhibits good oral anti tumor activity in mouse xenograft models. PHT 427 reduces the phosphorylation of AKT and PDPK1. Following the administration of a single oral dose of PHT 427 to mice bearing BxPC 3 human pancreatic tumor xenografts, PHT 427 inhibited the phosphorylation of both Akt and PDPK1 as well as downstream targets
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