GS-444217 LSB Smiles: CC(C)N(CCNC(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1Cl

Smiles: CC(C)N(CCNC(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1Cl

(2012) PCT WO 2012009678

GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1

Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion

1H3/b20-12+

GS-444217 LSB Smiles: CC(C)N(CCNC(C)C)S(=O)(=O)C1=CC=C(Cl)C=C1ClGS 444217 (ASK1 IN 1) is a potent, selective, orally available and ATP competitive inhibitor of ASK1 (apoptosis signal regulating kinase 1) with IC50 of 2. 87 nM. Product information CAS Number: 1262041 49 5 Molecular Weight: 411. 46 Formula: C23H21N7O Synonym: ASK1 IN 1 Chemical Name: 4 (4 Cyclopropyl 1H imidazol 1 yl) N (3 (4 cyclopropyl 4H 1,2,4 triazol 3 yl)phenyl)picolinamide Smiles: O=C(NC1=CC(=CC=C1)C1=NN=CN1C1CC1)C1=CC(=CC=N1)N1C=C(N=C1)C1CC1