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is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively)
Chemical Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-1-fluoro-5H-dibenzo[b
13(1):e0191010
resulted in normalization of hypertensive blood pressure in a rat model of CKD
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach
ALK2-IN-4 succinate - CAS# 2416307-25-8 60430 is a selective ERβ receptorALK2 IN 4 succinate, CAS No. 2416307 25 8, is a potent ALK2 inhibitor extracted from patent WO2020086963A1, compound Formula I free base. Product information CAS Number: 2416307 25 8 Molecular Weight: 593. 65 Formula: C30H36FN7O5 Chemical Name: ALK2 IN 4 succinate Smiles: CN1CCN(CC1)C1CCN(CC1)C1=CN2N=CC(=C2N=C1)C1=CC=NC2=CC(F)=C(C=C12)OC. OC(=O)CCC(O)=O InChiKey: HSNCQJZBFVYYOY UHFFFAOYSA N InChi: InChI=1S C26H30FN7O. C4H6O4 c1 31 9 11 33(12 10 31)18
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