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2014 Dec 19
Formula: C14H14ClFN8
InChi: InChI=1S/C29H34N6O
Barrett MP
In H4 cells expressing the mCherry-GFP-LC3 reporter PIK-III inhibits the formation of mCherry-positive autolysosomes and increases the cytosolic signal of LC3 under basal conditions and when autophagy is induced with the mTOR inhibitor AZD8055
LW 6 - CAS# 934593-90-5 0185 2014 Dec 19LW 6, CAS No. 934593 90 5, was first identified and reported by a group scientists from Korea. LW8 was found to inhibits the accumulation of HIF 1alpha. LW6 decreased HIF 1alpha protein expression without affecting HIF 1beta expression. It was further found that LW8 promoted the degradation of wild type HIF 1alpha, but not of a DM HIF 1alpha with modifications of P402A and P564A, at hydroxylation sites in the oxygen dependent degradation domain