DAPT - γ-secretase Inhibitor. CAS# 208255-80-5 Catalog No.:M60023-2S N[C@@H](CC1C=CC(=CC=1)[N+]([O-])(CCCl)CCCl)C(O)=O

N[C@@H](CC1C=CC(=CC=1)[N+]([O-])(CCCl)CCCl)C(O)=O

Cocktail Formulation: 3 mM CHIR99021 and 2 mM SB431542 in DMSO solution Effective Concentration in Cell Culture: 3 µM CHIR99021 and 2 µM SB431542 in cell culture medium

InChi: InChI=1S/C18H22N2O/c21-18(13-6-2-1-3-7-13)10-16-14-8-4-5-9-15(14)17-11-19-12-20(16)17/h4-5

(2016) Science

even at a concentration of 0

DAPT - γ-secretase Inhibitor. CAS# 208255-80-5 Catalog No.:M60023-2S N[C@@H](CC1C=CC(=CC=1)[N+]([O-])(CCCl)CCCl)C(O)=ODAPT, CAS No. 208255 80 5, is a widely used secretase inhibitor and serves as an inhibitor of Notch, a secretase substrate. It can also cause a reduction in A40 and A42 levels in human primary neuronal cells (IC50 ~115 nM for total A and ~200 nM for A42) and in brain extracts, as well as in vivo. Since the Notch pathway is involved in development of many cell types, DAPT is used to modulate Notch activity in ESC iPSC or adult stem cell differentiation