Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid CGK733 (10 μM) results in

CGK733 (10 μM) results in 1

is a potent and selective and orally active PRMT5 inhibitor with a half-maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases

Combining P5091 with lenalidomide

and has slight activity against HDAC8 (IC50 ~0

GNF4877 was orally dosed to mice at 50 mg/kg twice a day for 14 days

Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid CGK733 (10 μM) results inRapamycin, CAS No. 53123 88 9, is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism