Scopine Hydrochloride 0185 4-dihydro-1(2H)-quinolinyl)-2-oxoethoxy]carbonyl]hydrazide

4-dihydro-1(2H)-quinolinyl)-2-oxoethoxy]carbonyl]hydrazide

cabazitaxel penetrates the blood-brain barrier (BBB)

Smiles: COC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NCCC(C)(C)C

Smiles: C[C@H](O)[C@H](CC)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(C=C1)OC[C@H]1C[C@@](CN2C=NC=N2)(OC1)C1=CC=C(F)C=C1F

with IC50s of 102 ± 19 nM and 276 ± 26 nM

Scopine Hydrochloride 0185 4-dihydro-1(2H)-quinolinyl)-2-oxoethoxy]carbonyl]hydrazideScopine HCl is a metabolite of the muscarinic antagonist scopolamine. Scopine binds to muscarinic acetylcholine receptors and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors. It reduces hyperphagia induced by the antipsychotics loxapine and chlorpromazine. When conjugated to chlorambucil, scopine improves the blood brain barrier permeability of chlorambucil. Product information CAS Number: 85700 55 6