CHMFL-EGFR-202 Size:Contact [email protected] for quotation Tsvetkov DE

Tsvetkov DE

DMU-212 induces mitotic arrest via induction of apoptosis and activation of ERK1/2 protein

CAS Number: 379270-38-9

InChi: InChI=1S/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H

CAS Number: 1189957-99-0

CHMFL-EGFR-202 Size:Contact [email protected] for quotation Tsvetkov DECHMFL EGFR 202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5. 3 nM and 8. 3 nM for drug resistant mutant EGFR T790M and WT EGFR kinases, respectively. CHMFL EGFR 202 exhibits 10 fold selectivity for EGFR L858R T790M against the EGFR wild type in cells. CHMFL EGFR 202 adopts a covalent DFG in C helix out inactive binding conformation with EGFR, with strong antiproliferative effects against