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Chemical Name: N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S
1371/journal
InChiKey: NYHXPFHFIMRKDS-UHFFFAOYSA-N
Chemical Name: 2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3
or 75 mg/kg causes tumor growth inhibition with TGI of 19%
AZD-5438 702 Chemical Name: N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2SAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.
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