PI3Kα/mTOR-IN-1 Catalog No.:M18955-C 3-thiazol-4-yl)hepta-2

3-thiazol-4-yl)hepta-2

PNU-288034 is metabolically stable in liver microsomes across species

4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-2-oxo-1

THZ1 (10 mg/kg) demonstrates potent killing of primary chronic lymphocytic leukemia (CLL) cells and anti-proliferative activity against primary TALL cells and in vivo against a human T-ALL xenograft

as well as decreased expressions of collagen II and aggrecan

PI3Kα/mTOR-IN-1 Catalog No.:M18955-C 3-thiazol-4-yl)hepta-2PI3K mTOR IN 1 is a potent PI3K mTOR dual inhibitor, with an IC50 of 7 nM for PI3K in a cell assay, and Kis of 10. 6 nM and 12. 5 nM for mTOR and PI3K in a cell free assay , respectively. Product information CAS Number: 1013098 90 2 Molecular Weight: 310. 35 Formula: C16H18N6O Chemical Name: 2 amino 8 cyclopentyl 4 methyl 6 (1H pyrazol 4 yl) 7H,8H pyrido[2,3 d]pyrimidin 7 one Smiles: CC1N=C(N)N=C2C=1C=C(C(=O)N2C1CCCC1)C1=CNN=C1 InChiKey: