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Ayrapetov MK
is a potent and selective ATP-competitive inhibitor of mTOR with IC50 ~3
503(7477):493-9
Bioymifi is capable of acting as a single agent to induce DR5 clustering and aggregation
InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9
Harmine - DYRK1A Inhibitor. CAS# 442-51-3 size:10 mg solid Ayrapetov MKHarmine, CAS No. 442 51 3, is a potent, selective and orally bioavailable DYRK1A inhibitor with IC50 of 80 nM. It inhibits phosphorylation of tau directly by DYRK1A (IC50 ~700 nM). It has >10 fold selectivity over DYRK3 and DYRK2 (IC50 ~800 nM and 900 nM respectively. Harmine is also a unique regulator of PPAR expression that acts by inhibiting the Wnt signalling pathway in a cell specific manner. It attenuates inflammatory gene expression (TNF, IL 1,
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