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A saponin component from Dipsacus asper wall
16(10)23)17(11)24/h11-13
3)21-15-19(16-22(25(21)32)28(4
also known as Olbemox and K-9321
Solubility: DMSO : 100 mg/mL (173
COTI-2 nositol A saponin component from DipsacusCOTI 2, an anti cancer drug with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI 2 acts both by reactivating mutant p53 and inhibiting the PI3K AKT mTOR pathway. COTI 2 induces apoptosis in multiple human tumor cell lines. COTI 2 exhibits antitumor activity in HNSCC through p53 dependent and independent mechanisms. COTI 2 converts mutant p53 to wild type conformation. Product information CAS Number: 1039455 84