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6-dimethyl-3-oxo-3H-phenoxazine-1
Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
4]diazepin-6-yl)-4
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity
ATP (disodium salt) quantel 6-dimethyl-3-oxo-3H-phenoxazine-1RO4987655, also known as CH4987655, is an orally active small molecule, targeting mitogen activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor RO4987655 binds to and inhibits MEK, which may result in the inhibition of MEK dependent cell signaling and the inhibition of tumor cell proliferation. MEK, a dual specificity threonine tyrosine kinase, is a key component of the RAS RAF MEK ERK signaling