EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 Therefore KDM5-C70 was developed as

Therefore KDM5-C70 was developed as a pro-drug

Chemical Name: 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2

Bortezomib or Imatinib for synergistic activity

HS Tariff Code: 382200

H3K27 methylations play important roles in regulating gene expression through the polycomb-repressive complex (PRC1 or PRC2)

EX-527 - SIRT1 Inhibitor. CAS# 49843-98-3 60071 Therefore KDM5-C70 was developed asEX 527, CAS No. 49843 98 3, is a highly potent and selective inhibitor of SIRT1 with an IC50 ~98 nM. It does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members (IC50 ~20 100 M). EX 527 has been used to investigate the relationship between SIRT1 mediated deacetylation of p53, p53 activity, and cell survival following DNA damage, as well as many other biological processes involving SIRT1. Product information CAS Number: