VcMMAE Size:Solid 10 mg Smiles: C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]([C@H](O)[C@@H](O)C=O)[C@H](O)CO)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O

Smiles: C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]([C@H](O)[C@@H](O)C=O)[C@H](O)CO)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O

IC87114 (5 µM) potently inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated phosphatidylinositol triphosphate (PIP3) biosynthesis and chemotaxis

Molecular Weight: 493

Smiles: O[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)CO

Results demonstrates that the combined use of Celecoxib and fasudil significantly decreases COX-2 and Rho kinase II expression surrounding the lesion site in rats with spinal cord injury

VcMMAE Size:Solid 10 mg Smiles: C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]([C@H](O)[C@@H](O)C=O)[C@H](O)CO)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1OVcMMAE is a MMAE derivative with valine citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine citrulline (vc). Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to