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AP14145 hydrochloride Size:Contact [email protected] for quotation also known as ONO 1206

SKU: 47804683486

4.4
USD120.00 USD143.00

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Description

also known as ONO 1206 and OP1206

It is one of the treatments of choice for Prinzmetal angina

Smiles: CC1=NC=C(C=C1C1=CC(OC)=C(OC)C(=C1)OC)C1C=CC(=CC=1)N1CCNCC1

PF-4136309 is potent in inhibiting CCR2 mediated signaling events such as intracellular calcium mobilization and ERK (extracellular signal-regulated kinase) phosphorylation with IC50 values of 3

Chemical Name: 7-oxo-7H-benzo[de]benzo[4

AP14145 hydrochloride Size:Contact [email protected] for quotation also known as ONO 1206AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1. 1 M for KCa2. 2 (SK2) and KCa2. 3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant resistant porcine model of atrial fibrillation (AF). Product

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