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AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6
a fodder additive for poultry
Such an increase is significantly reduced by administration of INF39 (+2
an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides
and is weak or inactive as a GABA receptor agonist
Cilomilast-d9 ide D AZD-5991 S-enantiomer is a Mcl-1Cilomilast d9 (SB 207499 d9) is the deuterium labeled Cilomilast. Cilomilast (SB 207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC50s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 (IC50=74, 65, >100, and 83 M, respectively). Cilomilast has anti inflammatory and immunomodulatory effects and can be used for thr research of asthma