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6 µM but accelerates calcium deregulation and mitochondrial depolarization in glutamate-treated neurons
Epub 2011 Jan 21
The last 5-digit was used for name for easy communication
Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression
Chelsea E Powell
HLI 373 dihydrochloride Catalog No.:M8040-10 6 µM but accelerates calciumHLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) that blocks Hdm2 mediated ubiquitylation and proteasomal degradation of p53. HLI 373 induces apoptosis in several tumor cell lines that express wild type p53 such as LOX IMVI, A549, HT1080 and U2OS. Product information CAS Number: 1782531 99 0 Molecular Weight: 414. 33 Formula: C18H25Cl2N5O2 Chemical Name: 5 ((3 (dimethylamino)propyl)amino) 3, 10 dimethylpyrimido[4, 5 b]quinoline 2, 4(3H, 10H)
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