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and 10 (IC50 > 100 µM)
Epub 2013 Mar 14
Smiles: COC1=CC=CC=C1S(=O)(=O)NC1=CC2CN(C)C(=O)NC=2C=C1
CAS Number: 579515-63-2
282(33):24463-70
S1RA Size:Solid 10 mg and 10 (IC50 > 100E 52862, also known as S1RA and MR390, is a selective sigma 1 receptor antagonist, with a reported binding affinity of Ki = 17. 0 7. 0 nM, selective over the sigma 2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E