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Masanori Miwa
Chemical Name: 1-butyl-3-(naphthalene-1-carbonyl)-1H-indole
InChi: InChI=1S/C23H21N3O2/c1-3-8-16(9-4-1)19-20-22(24-14-18-12-7-13-27-18)25-15-26-23(20)28-21(19)17-10-5-2-6-11-17/h1-6
CAS Number: 849727-88-4
Smiles: CCOC1=CC2=NC=C(C#N)C(NC3=CC(Cl)=C(C=C3)OCC3=CC=CC=N3)=C2C=C1NC(=O)/C=C/CN(C)C
Cenobamate (YKP3089) Size:Contact [email protected] for quotation Masanori MiwaCenobamate, a sodium channel blocker, enhances GABAergic transmission and has the potential to be a versatile CNS drug. Cenobamate (YKP3089) protects against MES induced seizures in mice with an ED50 of 9. 8 mg kg i. p., and in rats with an ED50 of 1. 9 mg kg p. o. In the sc Met seizures model, Cenobamate given ip inhibited the clonic seizures in mice and rats, with ED50 values of 28. 5 and 13. 6 mg kg, respectively. Cenobamate is also effective