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Therapeutic Advances in Childhood Leukemia/Lymphoma Consortium
6H2/t15-/m0/s1
Epub 2014 Mar 16
CI-1040 treatment produces a reduction of pMAPK levels in multiple tumor cells including Colon 26
is a rationally designed
6-Mercaptopurine Catalog No.:M8131-10 Therapeutic Advances in Childhood Leukemia/LymphomaMercaptopurine is a thiopurine derivative antimetabolite with antineoplastic and immunosuppressive activities. Produced through the metabolism of mercaptopurine by hypoxanthine guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6 thioguanosine 5' phosphate (6 thioGMP) and 6 thioinosine (T IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA
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