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Ledipasvir (GS5885) is a HCV NS5A polymerase inhibitor
Smiles: C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=C(C=C43)OC)[C@@H]1CC[C@@H]2O
ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14
suggesting a lack of sympathetic activation
Treatment with BX471
Sildenafil Catalog No.:M10317-10 Ledipasvir (GS5885) is a HCVSildenafil is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5' cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro , synapto and angiogenesis in rat models of stroke and also is reported to be a mild vasodilator. Sildenafil has also been shown to prevent indomethacin induced small intestinal ulceration formation through an NO cGMP dependent
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