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2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-ol
66(1):404-11
Chemical Name: 6-[(3S
InChi: InChI=1S/C20H28O4/c1-16(2)9-6-4-5-7-11-20(22)24-14-8-10-17-12-13-18(21)19(15-17)23-3/h6
33(4):284-8
(S)-WAY 100135 dihydrochloride thacholine chloride 2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-ol(S) WAY 100135 dihydrochloride is a potent and selective antagonist of 5 HT1A receptor with IC50 value of 15 nM. The 5 HT1A receptor is a G protein coupled receptor for endogenous neurotransmitter serotonin (5 HT) and mediates inhibitory neurotransmission. (S) WAY 100135 dihydrochloride is a potent and selective somatodendritic and postsynaptic 5 HT1A receptors antagonist. (+ ) WAY100135 inhibited 5 HT1A receptor in the rat hippocampal with IC50 value
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