RS-1 - CRISPR Editing Enhancer. CAS# 312756-74-4 60423 Divergent synthesis of multifunctional molecular

Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors

Formula: C16H15BrClN3O2

in combination with bortezomib in multiple myeloma

in complex with the cytosolic protein FK-binding protein 12 (FKBP12)

and developmental potential

RS-1 - CRISPR Editing Enhancer. CAS# 312756-74-4 60423 Divergent synthesis of multifunctional molecularRS 1, CAS No. 312756 74 4, was previously characterized as a RAD51 Stimulatory compound and now found to be an HDR enhancer to enhance CRISPR Cas9 and TALEN mediated knock in efficiency. It increases the knock in efficiency by two to five fold at different loci, whereas NHEJ inhibitor SCR7 has minimal effects. RS 1 was applied for animal production and have achieved multifold improvement on the knock in rates as well. RS 1 can stimulate the human