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Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM)
LC-2-induced KRASG12C degradation occurs via a bona fide PROTAC mechanism
Treatment with 50 and 100 µM Pyrogallol decreases HPF viability by ~40 and 65% at 24 h
InChi: InChI=1S/C29H34O15/c1-11-20(31)23(34)25(36)28(41-11)40-10-18-21(32)24(35)26(37)29(44-18)43-17-9-16-19(22(33)27(17)39-3)14(30)8-15(42-16)12-4-6-13(38-2)7-5-12/h4-9
Charlene F
PROTAC PD-1/PD-L1 degrader-1 Size:100 mg solid Euphol inhibits the monoacylglycerol lipasePROTAC PD 1 PD L1 degrader 1, a PD 1 PD L1 degrader, inhibits PD 1 PD L1 interaction with an IC50 of 39. 2 nM. PROTAC PD 1 PD L1 degrader 1 significantly restores the immunity repressed in a co culture model of Hep3B OS 8 hPD L1 and CD3 T cells. PROTAC PD 1 PD L1 degrader 1 moderately reduces the protein levels of PD L1 in a lysosome dependent manner. Product information CAS Number: 2447066 37 5 Molecular Weight: 1076. 59 Formula: C59H58ClN7O11
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