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Smiles: CC1(COC2C=C3N=CN(C4=CC=C5C=CC=C(C5=N4)N4CCC(N)CC4)C3=CC=2)COC1
Pf-446687 is highly selective for MC4R and is both brain penetrant and stable in vivo
1-10 µM final concentration in various in vitro assays
Novartis discontinued development of mavoglurant for fragile X syndrome in April 2014 following disappointing trial results
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells
UBP-282 mulin Hydrochloride Smiles: CC1(COC2C=C3N=CN(C4=CC=C5C=CC=C(C5=N4)N4CCC(N)CC4)C3=CC=2)COC1UBP 282 is a potent, selective and competitive AMPA and kainate receptor antagonist. UBP 282 inhibits the fast component of the dorsal root evoked ventral root potential (fDR VRP) with an IC50 value of 10. 3 M. UBP 282 antagonizes kainate induced depolarisations of dorsal roots with a pA2 value of 4. 96. Product information CAS Number: 544697 47 4 Molecular Weight: 333. 30 Formula: C15H15N3O6 Chemical Name: 4 ({3 [(2S) 2 amino 2 carboxyethyl] 2,6
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