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and mitogenic signal transduction
identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells
thereby causing cell cycle arrest and inducing apoptosis in cells that overexpress PIMs
PubMed PMID: 24591668
Formula: C16H15NO7S
TH-237A hexiline Maleate and mitogenic signal transductionTH 237A is a novel neuroprotective agent, which possess protective properties against amyloid (A) induced neurodegeneration associated with Alzheimer's disease. Exposure of neuronal cultures to A peptide in the presence of 5 nM TH 237A resulted in a 50% increase in survival. Neuronal cultures treated with other toxic stimuli such as staurosporine, thapsigargin, paraquat and H2O2 showed significantly enhanced survival in the presence of TH 237A .
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