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Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
Atglistatin inhibited TG hydrolase activity of wild-type WAT in a dose-dependent manner up to 78% in animal models
inhibited PI3K γ and -δ(IC50 values of 83 and 235 nM
OF-1 was used at 5-10 µM final concentration in various in vitro assays
CC1(C)OC2=CC=C(NC3=NC(NC4C=C(OC)C(OC)=C(C=4)OC)=NC=C3F)N=C2N(COP([O-])([O-])=O)C1=O
Pifithrin-β ometazoline Hydrochloride Discovery and optimization of small-moleculePifithrin beta, also known as QB102 and Cyclic Pifithrin , is is p53 functional inhibitor. Pifithrin counteracts the Alzheimer peptide non amyloid component effects in human SH SY5Y cells. Product information CAS Number: 60477 34 1 Molecular Weight: 268. 38 Formula: C16H16N2S Chemical Name: 4 (4 methylphenyl) 7 thia 2,5 diazatricyclo[6. 4. 0. 0,]dodeca 1(8),3,5 triene Smiles: CC1C=CC(=CC=1)C1=CN2C(=N1)SC1CCCCC2=1 InChiKey: IMUKUMUNZJILCG UHFFFAOYSA N