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Burdelya L
Chemical Name: 1-tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3
GSK-872 (GSK'872
({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-ol
XL388 - CAS# 1251156-08-7 Catalog No.:M9702-10 Burdelya LXL388 is a Novel Class of Highly Potent, Selective, ATP Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR). XL388 inhibited cellular phosphorylation of mTOR complex 1 (p p70S6K, pS6, and p 4E BP1) and mTOR complex 2 (pAKT (S473)) substrates. XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability. Oral administration of XL388 to athymic nude mice implanted with
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