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EGF816 is well tolerated and possesses favorable physicochemical properties and good oral bioavailability in mice
3% (24 h)
InChiKey: HPSRPMOJFMXEKS-UHFFFAOYSA-N
32)34-24-22-29(3
CAS Number: 208459-17-0
8, 11, 14-Eicosatriynoic Acid 2iB EGF816 is well tolerated and8,11,14 Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12 lipoxygenase (12 LO), cyclooxygenase (COX), and 5 lipoxygenase (5 LO) with IC50 values of 0. 46 M, 14 M, and 25 M, respectively. Also, it inhibits the actions of slow reacting substance of anaphylaxis with an IC50 value of 10 M [1,2]. Lipoxygenases are found widely in fungi, plants, and animals in
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