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1186/s12967-015-0581-2
1 μM for both GNE-7915 (100-fold over LRRK2 Ki) and 19 (250-fold over LRRK2 Ki) resultes in only TTK showing greater than 50% inhibition
Chemical Name: N2-(1H-benzo[d]imidazol-6-yl)-N4-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2
and SMARCA2 even at 10 μM
Pauwels PJ
CZC-25146 - CAS# 1191911-26-8 0088 1186/s12967-015-0581-2CZC 25146, CAS No. 1191911 26 8, is a potent and selective LRRK2 inhibitor. Leucine rich repeat kinase 2 (LRRK2) mutations are the most important cause of familial Parkinson's disease. CZC 25146 prevents mutant LRRK2 induced injury of cultured rodent and human neurons with mid nanomolar potency. Product information CAS Number: 1191911 26 8 Molecular Weight: 488. 54 Formula: C22H25FN6O4S Synonym: CZC25146 CZC 25146 CZC 25146 Chemical Name: N (2 ((5
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