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BMS-986242 shows IC50>25 μM for all targets except nAChR a1 (IC50=12
In agreement with the in vitro study
Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation
Solubility: DMSO : ≥ 110 mg/mL (232
Smiles: C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
X-376 Size:Contact [email protected] for quotation BMS-986242 shows IC50>25 μM forX 376 is a potent and highly specific ALK tyrosine kinase inhibitor (TKI) (IC50=0. 61 nM). X 376 is a less potent inhibitor of MET (IC50=0. 69 nM). X 376 displays potent anti tumor activity. Product information CAS Number: 1365267 27 1 Molecular Weight: 547. 41 Formula: C25H25Cl2FN6O3 Chemical Name: 6 amino 5 [(1R) 1 (2,6 dichloro 3 fluorophenyl)ethoxy] N [4 (4 methylpiperazine 1 carbonyl)phenyl]pyridazine 3 carboxamide Smiles: