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Discovery of I-BRD9
CAS Number: 834903-43-4
with IC50 larger than 20 µM
7a-tetrahydro-4H-furo[3
Hájíček J
Clevudine Catalog No.:M9636-10 Discovery of I-BRD9Clevudine, also known as L FMAU, is an antiviral used in the treatment of Hepatitis B. Clevudine is differentiated from other oral agents by an unusual activation pathway to the biochemically active triphosphate, a mechanism of action of clevudine triphosphate that inhibits multiple steps of the hepatitis B virus (HBV) intracellular life cycle, a long half life, and significant reduction of covalently closed circular DNA (cccDNA) in animal models.