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The combination of YM155 and γ-radiation increases both the number of apoptotic cells and the activity of caspase-3
8-tetrahydro-[1
EW-7197 inhibits breast cancer metastasis to the lung
XPO1 target occupancy measurements confirm the KPT-330recommended phase 2 dose
LY411575 isomer 3
CZC-25146 Hydrochloride 64 2HCl The combination of YM155 andCZC 25146 is a potent and selective LRRK2 inhibitor. Leucine rich repeat kinase 2 (LRRK2) mutations are the most important cause of familial Parkinson's disease. CZC 25146 prevents mutant LRRK2 induced injury of cultured rodent and human neurons with mid nanomolar potency. Product information CAS Number: 1330003 04 7 Molecular Weight: 525. 00 Formula: C22H26ClFN6O4S Chemical Name: N {2 [(5 fluoro 2 {[2 methoxy 4 (morpholin 4 yl)phenyl]amino}pyrimidin
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