AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid Smiles: NC1N=C(C=C(NC2CC2)N=1)C1=CC=CC(Cl)=C1Cl

Smiles: NC1N=C(C=C(NC2CC2)N=1)C1=CC=CC(Cl)=C1Cl

04] in exponentially growing DNA-PK proficient but not deficient cells

and impairment of cell cycle progression and DNA damage repair pathways

Mordmüller B

104(7):1116-25

AZD8055 - mTOR Inhibitor. CAS# 1009298-09-2 size:2 mg solid Smiles: NC1N=C(C=C(NC2CC2)N=1)C1=CC=CC(Cl)=C1ClAZD8055, CAS No. 1009298 09 2, is a highly potent, selective and ATP competitive mTOR inhibitor (IC50 = 0. 8 nM). It has >1, 000 fold selectivity against all PI3K isoforms (, , , ) and other members of the PI3K like kinase family (ATM and DNA PK). It has no significant activity against a panel of 260 kinases at concentrations up to 10 M. AZD8055 inhibits the phosphorylation of mTORC1 downstream targets (p70S6K and 4E BP1) as well as phosphorylation of