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(2012) Nature Reviews Drug Discovery 11
Smiles: CC1C=CC(=CC=1)C1=CSC(=N1)C1=CC(CCC)=NC=C1
59865-13-3
Molecular Weight: 468
org/wiki/Monomethyl_auristatin_E
N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 (2012) Nature Reviews Drug DiscoveryN106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart
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