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154(9):4379-89
Psychopharmacol Bull
4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36
herbicides
2007 Mar 27
Folic acid Size:Solid 2 mg 154(9):4379-89ABT 100 is an orally bioavailable farnesyltransferase inhibitor. ABT 100 inhibited proliferation of cells in vitro carrying oncogenic H Ras (EJ 1 bladder; IC(50) 2. 2 nmol L), Ki Ras (DLD 1 colon, MDA MB 231 breast, HCT 116 colon, and MiaPaCa 2 pancreatic; IC(50) range, 3. 8 9. 2 nmol L), and wild type Ras (PC 3 and DU 145; IC(50), 70 and 818 nmol L, respectively) as well as clonogenic potential. ABT 100 shows 70% to 80% oral bioavailability in mice.
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