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PubMed PMID: 26701983
Sotrastaurin at day 26)
Chemical Name: 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-1
PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models
Pomalidomide4alkylC4
Aprepitant erin HCl PubMed PMID: 26701983Aprepitant is a small molecule, high affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P induced emesis. This agent has little or no affinity for serotonin type 3 (5 HT3), dopamine, and corticosteroid receptors.