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Epub 2013 Mar 1
123(6):2475-87
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
InChi: InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30
CAS Number: 1239908-20-3
AZD-2461 - CAS# 1174043-16-3 Catalog No.:M7107-2 Epub 2013 Mar 1AZD 2461, CAS No. 1174043 16 3, is a novel and potent PARP inhibitor with lower affinity to P glycoprotein. AZD2641 is currently in Phase I clinical study. The study is being conducted to see how it may work to treat solid tumors. The main purpose is to establish a safe dosage of the drug and provide additional information on any potential side effects this drug may cause. The study will also assess the blood levels and action of AZD2461 in the body
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