Rilmenidine hemifumarate iKan 083 Smiles: CC1=CC(=CC(C)=C1)C(=O)N(NC(=O)C1=CC=C2OCCCC2=C1C)C(C)(C)C

Smiles: CC1=CC(=CC(C)=C1)C(=O)N(NC(=O)C1=CC=C2OCCCC2=C1C)C(C)(C)C

4S)-4-amino-2-{[(1R)-1

InChiKey: NNACHAUCXXVJSP-UHFFFAOYSA-N

is an investigational drug candidate for metastatic colorectal cancer

Formula: C23H24N2O

Rilmenidine hemifumarate iKan 083 Smiles: CC1=CC(=CC(C)=C1)C(=O)N(NC(=O)C1=CC=C2OCCCC2=C1C)C(C)(C)CRilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2 adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+ H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic