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When mice that were transplanted with primary mouse T-ALL cells
Many tumors become addicted to autophagy for survival
INCB024360 was dosed at 75 mg/Kg (BID
It inhibited the activity of human PRC2-containing wild-type EZH2 with an inhibition constant (Ki) value of 2
97846-18-9
PF-04979064 - PI3K/mTOR Dual Inhibitor. CAS# 1220699-06-8 hylase When mice that were transplantedPF 04979064, CAS No. 1220699 06 8, is a highly potent and orally bioavailable PI3K mTOR dual inhibitor developed through structure based drug design. It inhibited mTOR, PI3K, , and isoforms and AKT phosphorylation with IC50 as 2. 64 nM, 0. 395 nM, 0. 111 nM, 0. 122 nM and 28. 3 nM, respectively. PF 04979064 exhibited cellular potency with an IC50 of 9. 1 nM in a BT20 cell assay. PF 04979064 exhibited excellent in vitro potency, very good solubility,
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US$ 180.27