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the anti-MM activity of ACY-1215 in combination with bortezomib was confirmed using 2 different xenograft SCID mouse models
and triggers cell cycle arrest and apoptosis across a large cell panel representing various non-Hodgkin’s lymphoma (NHL) subtypes
Ivosidenib (racemic)
Formula: C19H18N2O2
2% Tween 80) in the other animal studies
Mitoxantrone - CAS# 65271-80-9 035 the anti-MM activity of ACY-1215Mitoxantrone, CAS No. 65271 80 9, is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5. 3 M), thus inhibiting cell proliferation. It also inhibits HIV 1 integrase (IC50 = 3. 8 M). Mitoxantrone is exported from cells in an ATP and glutathione dependent manner by multidrug resistance protein 1. 4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis. Product information CAS
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