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SB505124 (10 µM) impairs Smad2 phosphorylation and CTGF and α-SMA expression in vitro
ML-109 is surprisingly stable at neutral and basic conditions (t1/2 of ~16 h) but is found to degrade at low pH (t1/2 of ~3 h)
2010 Sep 22
Smiles: NC1NN=CC=1C1=CC(Cl)=CC=C1OC1=CC(F)=C(C=C1Cl)S(=O)(=O)NC1=CSC=N1
which is an orally bioavailable
Clemizole Size:Solid 2 mg SB505124 (10 µM) impairs Smad2Clemizole is a histamine H1 blocker used to treat allergies. Product information CAS Number: 442 52 4 Molecular Weight: 325. 84 Formula: C19H20ClN3 Chemical Name: 1 [(4 chlorophenyl)methyl] 2 [(pyrrolidin 1 yl)methyl] 1H 1,3 benzodiazole Smiles: ClC1=CC=C(CN2C3=CC=CC=C3N=C2CN2CCCC2)C=C1 InChiKey: CJXAEXPPLWQRFR UHFFFAOYSA N InChi: InChI=1S C19H20ClN3 c20 16 9 7 15(8 10 16)13 23 18 6 2 1 5 17(18)21 19(23)14 22 11 3 4 12 22 h1 2,5 10H,3 4,11 14H2