GCN2-IN-6 L246) N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2=CC=C(C=C2)N2CCOCC2)=N1

N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2=CC=C(C=C2)N2CCOCC2)=N1

Solubility: DMSO: 25 mg/mL(97

InChiKey: GJAWHXHKYYXBSV-UHFFFAOYSA-N

05) on day 1 and by 41

Smiles: COCCOC1=CC2N=CN=C(NC3C=CC(=CC=3)NC(=O)CN3C=C(N=N3)C(C)C)C=2C(F)=C1

GCN2-IN-6 L246) N#CCNC(=O)C1C=CC(=CC=1)C1=CC=NC(NC2=CC=C(C=C2)N2CCOCC2)=N1GCN2 IN 6 (Compound 6d) is a potent, and orally available GCN2 inhibitor confirmed by in house enzymatic (IC50 of 1. 8 nM) and cellular assays (IC50 of 9. 3 nM). GCN2 IN 6 is also a eIF2 kinase PERK inhibitor with an IC50 of 0. 26 nM (in enzymatic assay) and 230 nM (in cells). Product information CAS Number: 2183470 09 7 Molecular Weight: 485. 29 Formula: C19H12Cl2F2N4O3S Chemical Name: N {3 [2 (2 aminopyrimidin 5 yl)ethynyl] 2,4 difluorophenyl} 2,5