Z-Asp-CH2-DCB - CAS# 153088-73-4 Size:2mg solid Chemical Name: 2-(5-chloro-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)-N-cyclopropyl-1-benzothiophene-4-carboxamide trihydrochloride

Chemical Name: 2-(5-chloro-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)-N-cyclopropyl-1-benzothiophene-4-carboxamide trihydrochloride

Formula: C17H23N3O2

33 - >100 nM after a 1 h exposure

Its enantiomer (S)-PFI-2 is 500-fold less active making it an excellent negative control

S)-AHPC-Me-C10-Br is a synthesized E3 ligase ligand-linker conjugate

Z-Asp-CH2-DCB - CAS# 153088-73-4 Size:2mg solid Chemical Name: 2-(5-chloro-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)-N-cyclopropyl-1-benzothiophene-4-carboxamide trihydrochlorideZ Asp CH2 DCB is an irreversible broad spectrum caspase inhibitor. Z Asp CH2 DCB also inhibits proteases with caspase like activity. Z D CH2 DCB blocks the production of IL 1, TNF , IL 6, and IFN in staphylococcal enterotoxin B (SEB) stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB 1 stimulated T cell proliferation in a dose dependent manner. Z Asp CH2 DCB prevents SU5416 induced septal cell apoptosis and emphysema development.