(S)-CPW 399 C-C8-NH2 dihydrochloride Smiles: CC1=C(/C=C2/C3=CC(F)=CC=C3NC/2=O)NC(C)=C1C(=O)NCCN1CCCC1

Smiles: CC1=C(/C=C2/C3=CC(F)=CC=C3NC/2=O)NC(C)=C1C(=O)NCCN1CCCC1

and 40 mg/kg) decreases serum uric acid levels and increases urinary urate excretion and fractional excretion of uric acid in hyperuricemic mice

In adult mice

PubMed PMID: 24519175

Formula: C141H218N40O48

(S)-CPW 399 C-C8-NH2 dihydrochloride Smiles: CC1=C(/C=C2/C3=CC(F)=CC=C3NC/2=O)NC(C)=C1C(=O)NCCN1CCCC1(S) CPW 399 is a potent and selective agonist of AMPA receptor with Ki value of 747 nM . The amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid receptor (AMPA receptor) is an ionotropic transmembrane receptor for glutamate and mediates fast synaptic transmission in the central nervous system. AMPA receptors are oligomeric assemblies of four protein subunits, GluR1 4. (S) CPW 399 is a potent and selective AMPA receptor agonist. (S) CPW 399 exhibited